Footnotes for "Fibropapilloma Tumors at Honokowai"

  1. Brodie, J., (June, 1995). The problem of nutrients and eutrophication in the Australian marine environment. In: WWW document: Pollution, Technical Annex: 2, State of the Marine Environment Report for Australia

    Eutrophication results from the supply of excessive plant nutrient substances to an aquatic ecosystem leading to enhanced plant growth or to a change in the composition of plant and other species.

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  2. Balazs, G.H., (1980). Synopsis of Biological Data on the Green Turtle in the Hawaiian Islands. U.S. Department of Commerce, National Oceaonographic and Atmosphere Administration, National Marine Fisheries Service, NOAA-TM-NMFS-SWFC-7, page 23:

    Green turtles that reside in coastal areas of the Hawaiian Archipelago have been documented by the author feeding on 56 species of algae, one marine angiosperm, and nine types of invertebrates. However, 9 species of algae out of approximately 400 species present in the Hawaiian Archipelago account for the major food sources utilized. Codium and ulva are major dietary components of juveniles, subadults, and adults in both segments of the Hawaiian Archipelago, joined by Pterocladia and Amansia in the main islands, and Caulerpa, Turbinaria, and Spyridia in the [Northwest Hawaiian Islands].

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  3. Herbst, L.H. (1995). Green Turtle Fibropapillomatosis: Challenges to Assessing the Role of Environmental Cofactors. In: Environmental Health Perspectives, Vol. 103, Supplement 4, May 1995. Page 29:

    Feeding grounds may attract a high density of susceptible turtles that would facilitate the transmission of pathogens in a density-dependent fashion, as has been shown for horizontally transmitted damselfish neurofibromatosis and the herpes virus of Lucke's renal adenocarcinoma.

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  4. Herbst, L.H., Jacobson, E.R., Moretti, R., Brown, T., Sundberg, J.P., and Klein, P.A. (1995). Experimental transmission of green turtle fibropapillomatosis using cell-free tumor extracts. In: Diseases of Aquatic Organisms, Vol. 22. Page 8:

    For example, papilloma viruses (papovaviridae) cause papillomas, fibromas, and fibropapilloma in many vertebrate species (Sundberg 1987) and have been observed in hyperplastic skin lesions of Bolivian side-necked turtles (Jacobson, et al. 1982).

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  5. Herbst, L.H. (1994). Fibropapillomatosis of Marine Turtles. In: Annual Review of Fish Diseases, Vol. 4. Page 411.

    The experimental evidence of Herbst et al. provides the clearest indication that an infectious subcellular agent, most probably a virus, is the etiology of GTFP. The agent responsible for positive experimental transmission has not yet been identified.

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  6. Cann, A.J. (Date unknown). Papovaviruses: Papillomaviruses: Replication. In: WWW document: Microbiology and Immunology, University of Leicester, Department of Microbiology & Immunology

    [The] virus is shed from epidermal cells when these are sloughed off and is transmitted by direct contact (esp. genital warts) and indirect contact.

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  7. Young, P., Veterinary Virologist, Animal Research Institute and Queensland Agricultural Biotechnology Centre, Brisbane, Australia (1995). Personal communication, used with permission.

    The fact that the turtles have fibropapilloma certainly means that mechanical transmission of tumor cells is possible. Cattle suffer from ocular papillomas and one theory is that these can be transmitted by flies etc if the flies actually pick up tumor cells and then carry these to another animal. The papilloma viruses aren't excreted (or at least not in large quantities) so cells are more efficient.

    Bovine papillomas are often transmitted during minor surgical procedures eg taking blood samples, skin biopsies etc.

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  8. Losey, G.S., Balazs, G.H., and Privitera, L.A. (1994). Cleaning Symbiosis between the Wrasse, Thalassoma duperry, and the Green Turtle, Chelonia mydas. In: Copeia, 1994, No. 3. Page 688.

    We estimate that five to 10 turtles "resident" at a cleaning station are required as a stable food source for a single specialized cleaner.

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  9. Losey, G.S., Balazs, G.H., and Privitera, L.A. (1994). Cleaning Symbiosis between the Wrasse, Thalassoma duperry, and the Green Turtle, Chelonia mydas. In: Copeia, 1994, No. 3. Page 689.

    Cleaners might even serve as a carrier or vector for the agent that causes the fibropapilloma.

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  10. Balazs, G.S., Forsyth, R.G., and Kam, A.K.H. (1985). Preliminary Assessment of Habitat Utilization by Hawaiian Green Turtles in Their Resident Foraging Pastures. U.S. Department of Commerce, National Oceaonographic and Atmosphere Administration, National Marine Fisheries Service, NOAA-TM-NMFS-SWFC-71 page 32:

    Skin diving conducted out to the breakers on the same morning revealed dense growths of algae, especially Codium spp., Gelidium sp., Acanthophora, and Pterocladia with entangled Ulva reticulata often growing on it. The depth in most of this area was only 1.0 to 1.5 m, with many calcareous outcroppings covered with Pterocladia exposed at low tide. The abundance of known food sources that exists at this site is undoubtedly correlated to the presence of turtles previously seen by Heacock.

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  11. Losey, G.S., Balazs, G.H., and Privitera, L.A. (1994). Cleaning Symbiosis between the Wrasse, Thalassoma duperry, and the Green Turtle, Chelonia mydas. In: Copeia, 1994, No. 3. Page 688.

    The wrasses have probably learned to recognize the barnacles as a food supply and how to remove this food in a manner that promotes cooperation and apparent solicitation by the turtles.

    Also:

    The opportunistic nature of T. duperry and the plasticity of its feeding habits argue for the likelihood of its learning to specialize on this food supply.

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  12. Herbst, L.H. (1994). Fibropapillomatosis of Marine Turtles. In: Annual Review of Fish Diseases, Vol. 4. Page 409.

    The epizootiologic patterns observed among free-ranging green turtle populations including the sudden appearance of GTFP at new geographic sites, variation in prevalence over relatively short distances, and temporal variation within a locality are compatible with an infectious etiology.

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  13. Herbst, L.H. (1994). Fibropapillomatosis of Marine Turtles. In: Annual Review of Fish Diseases, Vol. 4. Page 402.

    There are insufficient data to reconstruct the temporal and spatial pattern of disease spread among regions. The early reports from Florida and Malaysia suggest that the disease may have always had a worldwide albeit sporadic distribution.

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  14. Herbst, L.H. (1994). Fibropapillomatosis of Marine Turtles. In: Annual Review of Fish Diseases, Vol. 4. Page 407.

    Disease transmission would be enhanced by high population densities of vectors or intermediate host species, sediment types favoring pathogen survival outside the host, and low flushing rates. Some marine sites may attract a high density of susceptible turtles, which would facilitate the transmission of pathogens in a density-dependent fashion, as has been shown for horizontally transmitted damselfish neurofibromatosis and the herpes virus of Lucke's renal adenocarcinoma.

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  15. Woodward-Clyde Consultants, Marshall McCully & Associates, Inc., and Natural Systems Analysts, Inc. (1994). Preliminary Water and Sediment Quality Assessment of the Indian River Lagoon, Indian River Lagoon National Estuary Pogram, Melbourne, Florida. Final Technical Report. Page 5-71.

    Table 5-8 presents average values of water quality parameters from a study of Fellsmere Farms, Sebastian River, and Indian River Farms Water Control Districts (Harper and Marshall, 1993). This table shows that TKN, TN, and TP concentrations are consistently high compared to the Lagoon open water values shown in Table 5-5.

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  16. Bagley, D.A. (1995). Personal communication, used with permission.
    [Ehrhart] netted in various other spots in the early days, including much work in Mosquito Lagoon (during 70s) to the north, but found more turtles in the area we work today, so he concentrated on that area (since around 81 or 82).

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  17. Herbst, L.H. (1994). Fibropapillomatosis of Marine Turtles. In: Annual Review of Fish Diseases, Vol. 4. Page 402.

    Large differences in prevalence among demographically matched populations may be found over very short distances, (<1 km) as seen, for example, by comparing the prevalence of GTFP in the Indian River (about 50%) with that from the nearshore Sabellariid worm reef on the ocean side of the barrier island at Wabasso Beach (0%).

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  18. Brodie, J., (June, 1995). The problem of nutrients and eutrophication in the Australian marine environment. In: WWW document: Pollution, Technical Annex: 2, State of the Marine Environment Report for Australia

    Coastal eutrophication is recognised as a worldwide and growing problem in areas affected by agricultural and urban run-off (GESAMP 1990; Nixon 1990; Smayda 1990; Rosenberg 1985). Some of the problems in Australian fresh and marine waters have been summarised in recent publications (e.g. Brodie et al. 1990; AEC 1987; Cullen 1986). The principal nutrients associated with eutrophication are nitrogen (N) and phosphorus (P) but others such as organic carbon, silicon, iron, molybdenum and manganese may play a supplementary role. On a global scale, it is now estimated that the input of nutrients to the oceans from human sources via rivers is equal to, or greater than, the natural input (Windom 1992).

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